Outcome of myeloablative allogeneic stem cell transplantation in multiple myeloma with a 153Sm-EDTMP-based preparative regimen
نویسندگان
چکیده
منابع مشابه
Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma.
OBJECTIVE To present an institution's 2-year experience of non-myeloablative allogeneic stem cell transplantation among Chinese patients. DESIGN Retrospective study. SETTING Bone marrow transplantation unit at a university hospital, Hong Kong. PATIENTS Ten patients with multiple myeloma who received non-myeloablative allogeneic stem cell transplantation between March 2000 and October 2002...
متن کاملReduced intensity allogeneic stem cell transplantation in multiple myeloma.
Allogeneic stem cell transplantation (SCT) is an attractive form of immunotherapy for multiple myeloma (MM) due to well documented graft versus myeloma activity. High transplant related mortality with allogeneic SCT is currently the major limitation to wider use of this potentially curative modality. Mortality can be significantly reduced through the use of lower intensity conditioning regimens...
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Current myeloablative conditioning regimens for hematopoietic stem cell (HSC) transplantation are associated with significant morbidity and mortality. Thus, alternative strategies to promote engraftment of infused HSCs with increased safety warrant investigation. Using parabiotic mice, we determined that, after mobilization with AMD3100 (a CXCR4 antagonist), HSCs exited from marrow, transited b...
متن کاملSafe and effective use of outpatient non-myeloablative allogeneic stem cell transplantation for myeloma
Multiple myeloma (MM) remains incurable despite widespread deployment of novel agents and high-dose melphalan/autologous stem cell transplantation (ASCT) earlier in the disease course. Recently, non-myeloablative (NMA) allogeneic stem cell transplantation (allo SCT) has been introduced in an attempt to exploit the well-documented graft-versus-myeloma effect (GVM), while at the same time reducin...
متن کاملOutcome of allogeneic hematopoietic stem-cell transplantation for multiple myeloma: retrospective analysis of 16 patients
The role of allogeneic hematopoietic stem cell transplantation (allo-SCT) for multiple myeloma (MM) has not yet been established. We performed allo-SCT on 16 patients with MM in our hospital and an associated center, and retrospectively evaluated its efficacy. The median age at allo-SCT was 47 years. Eight patients underwent allo-SCT as a front-line therapy. Non-myeloablative treatment was prov...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2005
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2403698